Agrosuppression: A Bioassay for the Hypersensitive Response Suited to High-Throughput Screening

Add-on for High Throughput Screening in Material Discovery for Organic Electronics: “Tagging” Molecules to Address the Device Considerations

This work reflects the worth of intelligent modeling in controlling the nanostructure morphology in manufacturing organic bulk heterojunction (BHJ) solar cells. It suggests the idea of screening the pool of material design possibilities inspired by machine learning. To fulfill this goal, a set of experimental data on a BHJ solar cell with a donor structure of diketopyrrolopyrrole (DDP) and ...

Hypoxia response: a model toxicity pathway for high-throughput screening.

The identification of toxicity pathways associated with known adverse health effects combined with engineered cellular assays that measure perturbations of these pathways is the keystone to the successful implementation of the recently formulated National Research Council (2007) report, Toxicity Testing in the 21st Century: A Vision and a Strategy. While the toxicology community probes biologic...

A novel yeast bioassay for high - throughput screening of 3 matrix metalloproteinase inhibitors

24 25 Diverse malfunctions in the expression and regulation of matrix metalloproteinases (MMPs) are 26 often the cause of severe human diseases, bringing the identification of specific MMP-inhibitors 27 into major focus particularly in anti-cancer treatment. Here we describe a novel bioassay based 28 on recombinant yeast cells (Pichia pastoris) which express, deliver and incorporate biologicall...

Virtual screening: a real screening complement to high-throughput screening.

Virtual screening is being routinely used as an integral part of today's hit-identification strategies for, on one hand, prioritizing large corporate screening collections and, on the other hand, to extend the scope of screening to external databases. A brief description of the essential elements required for virtual screening and an application example to the identification of agonist hits for...

Bioassay Ontology to Describe High-Throughput Screening Assays and their Results